|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.
|
22634756 |
2012 |
|
Papillary Renal Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Whole exome sequencing showed a KMT2C-specific pathogenic mutation among all PAs and PRCCs.
|
31381885 |
2019 |
|
Papillary adenoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Whole exome sequencing showed a KMT2C-specific pathogenic mutation among all PAs and PRCCs.
|
31381885 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Whole exome sequencing (n=22, with paired tumor/germline DNA) and/or targeted deep sequencing (n=24) showed recurrent mutations of epigenetic modifiers in 74% of cases, involving notably KMT2C (26%), KMT2D (9%), CHD2 (15%) and CREBBP (15%).
|
31774495 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas KMT2C loss disrupts estrogen-driven proliferation, it conversely promotes tumor outgrowth under hormone-depleted conditions.
|
29755131 |
2018 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We review the most recent evidence on the underlying roles of MLL3/MLL4 and UTX in cancer and highlight key outstanding questions to help drive future research and contribute to our fundamental understanding of cancer and facilitate identification of therapeutic opportunities.
|
27638352 |
2016 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
We review the most recent evidence on the underlying roles of MLL3/MLL4 and UTX in cancer and highlight key outstanding questions to help drive future research and contribute to our fundamental understanding of cancer and facilitate identification of therapeutic opportunities.
|
27638352 |
2016 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We propose that cancer-associated mutations in MLL3 and MLL4 exert their properties through the malfunction of Trr/MLL3/MLL4-dependent enhancers.
|
24656127 |
2014 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We propose that cancer-associated mutations in MLL3 and MLL4 exert their properties through the malfunction of Trr/MLL3/MLL4-dependent enhancers.
|
24656127 |
2014 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
We performed MLL3 chromatin immunoprecipitation sequencing (ChIP-seq) in breast cancer cells, and MLL3 was shown to occupy regions marked by FOXA1 occupancy and H3K4me1 and H3K4me2.
|
27926873 |
2016 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
We performed MLL3 chromatin immunoprecipitation sequencing (ChIP-seq) in breast cancer cells, and MLL3 was shown to occupy regions marked by FOXA1 occupancy and H3K4me1 and H3K4me2.
|
27926873 |
2016 |
|
Malignant Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
We next studied the two loci separately and found that age and cancer related methylation was solely a property of the pseudogene CpG island and that the MLL3 loci was unmethylated.
|
21853109 |
2011 |
|
Primary malignant neoplasm
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
We next studied the two loci separately and found that age and cancer related methylation was solely a property of the pseudogene CpG island and that the MLL3 loci was unmethylated.
|
21853109 |
2011 |
|
Autism Spectrum Disorders
|
0.020 |
Biomarker
|
disease |
BEFREE |
We identify three mosaic missense and likely-gene disrupting mutations in genes previously implicated in ASD (KMT2C, NCKAP1, and MYH10) in probands but none in siblings.
|
27632392 |
2016 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We identified EZH2, KMT2C, and CHD4 as important genes in glioma in addition to the known gene IDH1/2.
|
29272522 |
2017 |
|
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We furthermore identified genes with a significant trend correlating with age in the control (MLL3) or the schizophrenia group (SOX5, CTRL).
|
24287731 |
2014 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
We found that primary osteosarcoma cell lines showed the highest capacity of migration before mRNA KMT2C silencing and the highest capacity of invasion after mRNA KMT2C silencing; on the contrary, osteosarcoma metastatic cell line showed the highest capacity of migration after mRNA KMT2C silencing and the highest capacity of invasion before mRNA KMT2C silencing.
|
31337554 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We found that frameshift mutations of MLL3 in both CRC cells and primary tumor that were more common in cases with microsatellite instability.
|
21853109 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We find many oncogenes and tumor suppressors among the affected genes that are likely candidates for mediating MLL3/4 tumor suppression function.
|
30194301 |
2018 |
|
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We conclude that KMT2C is a key regulator of ERα activity whose loss uncouples breast cancer proliferation from hormone abundance.
|
29755131 |
2018 |
|
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We conclude that KMT2C is a key regulator of ERα activity whose loss uncouples breast cancer proliferation from hormone abundance.
|
29755131 |
2018 |
|
Colorectal Carcinoma
|
0.350 |
PosttranslationalModification
|
disease |
BEFREE |
We analyzed mutations of coding region and promoter methylation in MLL3 using 126 cases of colorectal cancer.
|
21853109 |
2011 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
We analyzed mutations of coding region and promoter methylation in MLL3 using 126 cases of colorectal cancer.
|
21853109 |
2011 |
|
Malignant neoplasm of larynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also found that MLL3 rs6943984 and rs4725443 polymorphisms had synergistic effects with smoking or alcohol drinking for the risk of laryngeal cancer.
|
26818916 |
2016 |
|
Carcinoma of larynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also found that MLL3 rs6943984 and rs4725443 polymorphisms had synergistic effects with smoking or alcohol drinking for the risk of laryngeal cancer.
|
26818916 |
2016 |